Drink Powders

Drink Powders

Exact Nature products exclusively use PNX-Zero Bio-ECS High Potency CBD Powder. This exceptional powder has been developed by our supplier PNX Botanicals to exceed industry standards for bloodstream absorption rates. Try any of these lightly flavored powders and you may have just found your favorite new way to take CBD!

Exact Nature Products Exclusively Use PNX-Zero Bio-ECS High Potency CBD Powder

Efficient CBD Delivery and High Bioavailability

The supplier of all Exact Nature products is PNX Botanicals, a processor and supplier on the leading edge of Research & Development of CBD delivery. One of the key challenges faced by companies producing CBD supplements is the low absorption rate of whole-plant hemp oil in the digestive system.

Typically, the human body absorbs only 10-20 percent of the CBD contained in hemp extracts when swallowed by mouth. This low absorption is due to high levels of non-soluble organic lipids—like oil, fats and waxes—which means that as much as 90 percent of CBD may not enter your bloodstream to deliver health benefits.

One reason many CBD products come in the form of tinctures, chewables, vape oils, and transdermal patches, consequently, is because they enter the bloodstream primarily and more efficiently via the body’s mucus membranes, skin, and airways. However, some of these non-traditional delivery systems can be highly inconvenient and, at times, serve to limit the number of customers willing to purchase and consume CBD. This is to say that most people prefer to get their CBD as a pill or food additive, so if a more efficient powder and capsule could be developed, the effectiveness of the CBD it delivered would be made much more effective.

In response to this CBD absorption problem, PNX developed its proprietary PNX-Zero Bio-ECS Powder to maximize the CBD uptake into the body’s endocannabinoid system (hence the “ECS” in the powder’s name).

PNX-Zero Bio-ECS is water-soluble, and readily absorbed in the digestive tract, meaning higher bioavailability than oil bases – and more potency for the same amount of CBD. PNX Bio-ECS Powder can be capsulized and used in drink powder form as it is in Exact Nature’s single-serve stickpacks. To be clear that this powder is that being used by Exact Nature, it will be referred to as Exact Nature’s PNX Bio-ECS CBD Powder.

Versatility and Convenience

Exact Nature’s PNX Bio-ECS CBD Powder has the advantage of being far more versatile than hemp extract oils, which can be difficult to formulate and use to manufacture retail products. Hemp extract in an oil form will stick to just about everything, tastes bad for many users – and dissolves in just about nothing other than alcohols and oils. In short, formulating with hemp extract is challenging.

Exact Nature’s PNX Bio-ECS Powder, by contrast, can simply be mixed into food and beverage products, almost without exception, including protein shakes, juices, soft drinks, coffee, tea, baked goods or frozen goods, or simply added to a glass of water.

To develop the Exact Nature’s Bio-ECS CBD Powder, PNX utilized the principle of S-SEDDS (i.e., solid, self-emulsifying drug delivery systems) to create its highly bioavailable and stable CBD delivery system.

Zero THC Guaranteed

Exact Nature will not accept even trace amounts of THC in our products. Exact Nature’s Bio-ECS CBD Powder is the solution. Each batch is tested to 10 parts per million and is therefore safe for those that require absolute assurance that no THC reaches the bloodstream.

Clean, Sustainable, Health-Conscious

Exact Nature’s Bio-ECS CBD Powder is made from 100 percent organic plant materials. It is non-GMO, gluten free, vegan, kosher and uses no preservatives. Exact Nature’s hemp is grown organically outdoors, without the use of pesticides or herbicides.

Hemp byproducts are completely utilized for fiber, animal bedding and biomass energy. The hemp is CO2 extracted with no co-solvents. Exact Nature’s Bio-ECS CBD Powder does not come into contact with any solvents or chemicals at any stage in production.

Ways to Use

Exact Nature’s Bio-ECS CBD Powder contains no milk, egg, peanut, tree nut, fish, shellfish, soy or wheat allergens.

Exact Nature’s Bio-ECS CBD Powder can be consumed as any CBD product/ingredient with the expectation of higher potency compared to oil-based CBD. However, Exact Nature’s Bio-ECS CBD Powder is primarily intended for oral/gastrointestinal ingestion.

Suggested uses:
• Mix with water
• Protein shake additive
• Added to juice, health beverages, tea, beer, energy drinks or soft drinks
• Food additive

Better Than CBD Oil

CBD in oil form does not absorb well in the human body, outside of the mucus membranes. But Exact Nature’s Bio-ECS CBD Powder does. Exact Nature’s Bio-ECS CBD Powder is from 100 percent natural whole-plant hemp extract. Exact Nature’s Bio-ECS CBD Powder is self-emulsifying CBD and reaches the blood at far higher rates than CBD in hemp oil. This means you do not have to use as much CBD in your product to deliver results. A 1 mg dose of PNX Bio-ECS Powder will deliver the equivalent of 5-10 mg dose of an oil-based product. The reason for a water-soluble CBD is obvious: Higher CBD potency from a lower dose. This means your company will be able to offer a superior product with a strong health narrative to back it.

Top Selling CBD Powder vs. Exact Nature’s Bio-ECS CBD Powder

To help understand the contrast in the effectiveness of the two types of powders, PNX conducted an experiment. They took 200 mg of a leading CBD powder and 200 mg of Exact Nature’s Bio-ECS CBD Powder, mixed them into 60 ml of water at 45° C and stirred them to achieve maximum water absorption and particle dispersion.

Conclusion

Exact Nature’s Bio-ECS CBD Powder is superior in terms of solubility, stability of solution by a factor of at least 15x. Based on equivalent solubility/dispersion trials, it is projected that that 1 mg of CBD delivered orally in Exact Nature’s Bio-ECS CBD Powder should reach the bloodstream at a rate of at >10:1 over the leading brand. In vivo clinical trials are required to verify estimated bioavailability data.

Overview of the science behind

S-SEDDS: Solid, Self-Emulsifying Drug Delivery System.

Exact Nature’s Bio-ECS CBD Powder was developed based on the principle of S-SEDDS (Solid, Self-Emulsifying Drug Delivery System), a method designed to increase bioavailability, and in turn, the therapeutic effectiveness of hydrophobic drugs, particularly those administered orally.

S-SEDDS is firmly established as a platform technology for the formulation of poorly-soluble compounds and applies directly to CBD oil – as hemp extracts naturally exhibit extremely low aqueous solubility and poor vesicular delivery via the gastrointestinal tract.

The US Pharmacopeia requires that a compound break down in water within 45 minutes, at 37°c (human body temperature), while being agitated in laboratory equipment designed to simulate peristalsis, to simulate the muscular action of the stomach and gastrointestinal tract.

The fundamental science is that, if a substance can break down in water which has a neutral pH of about 7, then it should efficaciously break down in highly acidic gastric juices with a pH of 1.5 to 3.5.

Exact Nature’s Bio-ECS CBD Powder meets and exceeds these criteria. When introduced to an aqueous phase and after gentle agitation at temperatures as low as 25° C, Exact Nature’s Bio-ECS CBD Powder forms a stable a hydrocolloid dispersion (a stable o/w suspension or emulsion), that will not physically separate.

While cannabidiol has not been specifically classified by the FDA under the Biopharmaceutics Classification System (BCS), hemp extract best fits BCS Class II, meaning that CBD is highly permeable (across human intestinal membrane) but has low (water) solubility.

This class of supplements is best is suited to self-emulsifying delivery systems like SSEDDS. Active ingredients in self-emulsifying delivery systems similar to that of PNX Bio-ECS Powder have been clinically proven to dramatically increase gastrointestinal absorption of active ingredients at rates of up to 100%. Even 50% absorption would represent a 500-fold increase in CBD potency compared to non-soluble oilbased dose of CBD of the same size.

Taken in solid (powder) form, such as in a capsule or pill, PNX’s self-emulsifying formulation is readily dispersed in the gastrointestinal tract, the same as it is in a glass of water, where the motility of the stomach and small intestine provide the agitation necessary for emulsification.

S-SEDDS has gained attention due to enhanced oral bioavailability enabling reduction in dose, more consistent temporal profiles of active absorption, selective targeting of active ingredients toward specific absorption window in the gastrointestinal tract, and protection of active ingredients from the hostile environment in the gut.

The advantages and potential advantages of the self-emulsifying systems include 100% active ingredient entrapment capacity, physically stable formulation and formation of submicron droplet sizes (thus increasing absorption surface area), increase in rate and extent of absorption, and increased bioavailability of active ingredient. The pharmacokinetic properties achieved by S-SEDDS advance the rate of absorption and reduce, or eliminate, hepatic first-pass metabolism. This means that the active ingredient, in this case CBD, is expected to enter the blood stream in far greater quantities compared to an oil based form.

How many of the stickacks do I need to take?
For the Detox and Serenity Drink Powders, Exact Nature suggests pouring one stickpack into a bottle with 500 ml (or less) of water and shake vigorously. Drink this lightly flavored pick-me-ups all at once or sip it at your leisure. We suggest one single-serve stickpack a day, or two if possible. Exact Nature’s CBD products work best with consistent use over time, so ideally, these stickpacks would be taken as a supplement to a second regimen of Detox and Serenity capsules or CBD oil. For the Zzzs, pour one stickpack into a bottle with 500 ml (or less) of water, shake vigorously, and drink an hour before bedtime.

Are Exact Nature’s drink powders different than drink powders from other CBD brands?
Yes, significantly so. Exact Nature’s Bio-ECS CBD Powders are not like other CBD powders – their absorption rates are exceptional, exceeding industry standards by significant margins. For instance, in-house tests from PNX Botanicals have shown it to reach the bloodstream at a rate of more than ten times greater than the leading CBD powder brand to which it was tested.

Do the drink powders work as well as the capsules and oils?
Exact Nature’s capsules and the powders both use Exact Nature’s Bio-ECS CBD Powders. This proprietary powder, developed by Exact Nature supplier PNX Botanicals, significantly improves on the absorption rates and time-to-absorption over leading CBD capsules currently on the market. Oils are most effective when absorbed through the mucus membranes in the mouth, more so than when the oil is swallowed straightaway.

Are Exact Nature’s drink powders safe for recovering addicts?
Yes, all Exact Nature products are THC free and safe for people in addiction recovery – there are no addictive substances in any Exact Nature product. Each drink powder, in the form of single-serve stickpacks, is non-addictive and non-intoxicating.

Are Exact Nature’s drink powders addictive or habit forming?
No, not in any case. CBD is not addictive, nor is it habit forming. You could, however, get used to the positive way the drink powders make you feel and sleep and make it part of your daily routine. Detox Single-Serve Stickpacks are for curbing addictive cravings, Serenity Single-Serve Stickpacks are for mood and focus, and Zzzs Single-Serve Stickpacks are for better sleep.

Drink Powders

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